abstract：:During the assembly of the HLA class I molecules with peptides in the peptide-loading complex, a series of transient interactions are made with ER-resident chaperones. These interactions culminate in the trafficking of the HLA class I molecules to the cell surface and presentation of peptides to CD8(+) T lymphocytes. ...

journal_title：Scandinavian journal of immunology

authors： Cabrera CM

更新日期：2007-06-01 00:00:00

abstract：:Myasthenia gravis (MG) and its animal model experimental autoimmune MG (EAMG), are T-cell dependent, antibody-mediated autoimmune disorders. A dual altered peptide ligand (APL) composed of the tandemly arranged two single amino acids analogs of two myasthenogenic peptides, p195-212 and p259-271, was demonstrated to do...

journal_title：Scandinavian journal of immunology

authors： Ben-David H,Venkata Aruna B,Sela M,Mozes E

更新日期：2007-06-01 00:00:00

abstract：:Therapy with tumour necrosis factor-alpha (TNFalpha)-blocking agents is successful in treating inflammatory disorders, but carries an increased risk of manifest and reactivating infection with intracellular bacteria. In a mouse model of latent Salmonella typhimurium infection, neutralization of TNFalpha did not result...

journal_title：Scandinavian journal of immunology

authors： van Diepen A,Martina CA,Flierman R,Janssen R,van Dissel JT

更新日期：2007-05-01 00:00:00

abstract：:Ficolin-2 (L-ficolin), derived from the FCN2 gene, is an innate immunity pattern recognition molecule found in human serum in which inter-individual variation in serum appears to be under genetic control. To validate and extend this finding, we developed a sandwich ELISA for detection of human Ficolin-2 in serum sampl...

journal_title：Scandinavian journal of immunology

authors： Munthe-Fog L,Hummelshøj T,Hansen BE,Koch C,Madsen HO,Skjødt K,Garred P

更新日期：2007-04-01 00:00:00

abstract：:The possible immunological relationship between the pattern of Th1/Th2 cytokine production and tuberculin reactivity was assessed in patients with active Mycobacterium tuberculosis infection. The production of the intracellular cytokines interferon (IFN)-gamma and interleukin-4 (IL-4) was measured in CD4(+) and CD8(+)...

journal_title：Scandinavian journal of immunology

authors： Boras Z,Juretić A,Gagro A,Pavelić Lj

更新日期：2007-03-01 00:00:00

abstract：:The immune system of a healthy individual responds vigorously to foreign microbial antigens. However, all potentially immunogenic regions (determinants) within an antigen are not functionally of equal relevance in mediating host immunity against the pathogen. Moreover, some of these antigenic determinants are well pro...

journal_title：Scandinavian journal of immunology

authors： Sinha P,Snyder JA,Kim EY,Moudgil KD

更新日期：2007-02-01 00:00:00

abstract：:Understanding the specificity of antibody response to Neisseria meningitidis serogroup B (Men B) is a key requirement for the development of an effective vaccine. This study was designed to investigate the antigen specificity of murine IgG1 and IgG2b antibodies induced by different primary immunization schedules and t...

journal_title：Scandinavian journal of immunology

authors： Silva Junior FC,Gioia CA,Oliveira JM,Cruz SC,Frasch CE,Milagres LG

更新日期：2007-01-01 00:00:00

abstract：:Patients with juvenile idiopathic arthritis (JIA) have been shown to have elevated levels of circulating immune complexes (CICs) which correlated with disease activity. Our aim was to assess B cell activity by measuring the amount of and the kappa:lambda chain immunoglobulin light (L) chain ratio in CICs from JIA pati...

journal_title：Scandinavian journal of immunology

authors： Low JM,Chauhan AK,Moore TL

更新日期：2007-01-01 00:00:00

abstract：:Secretagogin is a newly identified calcium-binding protein selectively expressed in neuroendocrine tissue and pancreatic beta-cells. The function of secretagogin is unknown, but it has been suggested in beta-cells to influence calcium-influx, insulin secretion and proliferation, and has been observed downregulated in ...

journal_title：Scandinavian journal of immunology

authors： Skovhus KV,Bergholdt R,Erichsen C,Sparre T,Nerup J,Karlsen AE,Pociot F

更新日期：2006-12-01 00:00:00

abstract：:B cells are in analogy with T cells capable of expressing functional IL-2 receptors. IL-2R alpha-chain (CD25) positive T cells have been studied in detail but not much is known about CD25 positive B cells. The aim of this study was to examine the phenotypic properties of the CD25 expressing B cells collected from diff...

journal_title：Scandinavian journal of immunology

authors： Amu S,Gjertsson I,Tarkowski A,Brisslert M

更新日期：2006-11-01 00:00:00

abstract：:Human mast cell carboxypeptidase (hMC-CP) is a unique product of mast cells. Unlike tryptase and chymase, its potential function and expression in diseased conditions remain largely unknown. To develop an assay for hMC-CP, the recombinant fusion protein of hMC-CP and purified native skin hMC-CP was prepared, and two n...

journal_title：Scandinavian journal of immunology

authors： Zhou Y,Chen Z,He S

更新日期：2006-11-01 00:00:00

abstract：:The current critical shortage of human donor organs has stimulated the feasibility of the xenogenic transplantation, such as swine to primate. We have previously reported the induction of donor-specific tolerance in MHC-disparated recipient mice by using our cyclophosphamide (CP)-induced tolerance conditioning. In thi...

journal_title：Scandinavian journal of immunology

authors： Tomita Y,Shimizu I,Iwai T,Zhang QW,Okano S,Kajiwara T,Onzuka T,Tominaga R

更新日期：2006-10-01 00:00:00

abstract：:Sjögren's syndrome (SS) is a chronic inflammatory and lymphoproliferative autoimmune disease of unknown aetiology. It is characterised by progressive mononuclear cell infiltration of the salivary and lacrimal glands and a decreased glandular secretion, resulting in dryness of the mouth and eyes (xerostomia and keratoc...

journal_title：Scandinavian journal of immunology

authors： Vogelsang P,Jonsson MV,Dalvin ST,Appel S

更新日期：2006-09-01 00:00:00

abstract：:Systemic lupus erythematosus is a systemic autoimmune disorder of unknown aetiology but is most likely caused by an interaction between several genetic factors and the environment. In a previously published genome scan we presented linkage to a marker on chromosome 4p13 in Icelandic families. Fine mapping of the regio...

journal_title：Scandinavian journal of immunology

authors： Johansson CM,Kristjánsdottir H,Gröndal G,Steinsson K,Alarcón-Riquelme ME

更新日期：2006-09-01 00:00:00

abstract：:MTB12 protein, also called CFP-2, is a major and early secreted component of Mycobacterium tuberculosis. However, its role during mycobacterial infection has been poorly characterized. In this study, we purified the native MTB12 protein and investigated the profile of MTB12-induced cytokines [interferon (IFN)-gamma, t...

journal_title：Scandinavian journal of immunology

authors： Lee JS,Son JW,Jung SB,Kwon YM,Yang CS,Oh JH,Song CH,Kim HJ,Park JK,Paik TH,Jo EK

更新日期：2006-08-01 00:00:00

abstract：:The binding of human serum amyloid P component (SAP) to blood cells and monocyte-derived dendritic cells was investigated by flow cytometry. Monocytes bound biotinylated SAP with avidity in a dose-dependent and saturable manner. By contrast, the binding of SAP to monocyte-derived dendritic cells was weak. No binding t...

journal_title：Scandinavian journal of immunology

authors： Macdonald SL,Kilpatrick DC

更新日期：2006-07-01 00:00:00

abstract：:The cellular and humoral natural immune response induced by hepatitis C virus (HCV) is commonly unable to eradicate the virus. HCV is a highly mutable, hepatotropic RNA virus that causes acute and chronic hepatitis, an infection that involves the production of various cytokines. The aim of the study is to analyse the ...

journal_title：Scandinavian journal of immunology

authors： Gutierrez-Reyes G,Lopez-Ortal P,Sixtos S,Cruz S,Ramirez-Iglesias MT,Gutierrez-Ruiz MC,Sanchez-Avila F,Roldan E,Vargas-Vorackova F,Kershenobich D

更新日期：2006-06-01 00:00:00

abstract：:Mice homologous for the alymphoplasia mutation (aly) show the systemic absence of secondary lymphoid tissues, with disorganized splenic architecture, including the absence of the germinal centre and follicular dendritic cells. In this study, we examined the influence of defects of gut-associated lymphoid tissue (GALT)...

journal_title：Scandinavian journal of immunology

authors： Morimoto M,Yamauchi Y,Shinkawa S,Ishiwata K,Hayashi T

更新日期：2006-05-01 00:00:00

abstract：:B-Lymphocyte-activating factor (BAFF/BLyS) is a survival factor for B cells, belonging to the tumor necrosis ligand super family. Serum BAFF levels have been found to be elevated in patients with systemic lupus erythematosus (SLE). Neutralization of BAFF activity was suggested as an additional therapeutic approach in ...

journal_title：Scandinavian journal of immunology

authors： Toubi E,Kessel A,Rosner I,Rozenbaum M,Paran D,Shoenfeld Y

更新日期：2006-04-01 00:00:00

abstract：:Chlamydia pneumoniae initiates infection in humans via the mucosal epithelia of the respiratory tract; therefore, immunity at this mucosal site is believed to be important to control infection with this pathogen. We compared the protective capacity of immunization in mice with two C. pneumoniae antigens, namely the ma...

journal_title：Scandinavian journal of immunology

authors： Rodríguez A,Rottenberg M,Tjärnlund A,Fernández C

更新日期：2006-03-01 00:00:00

abstract：:We have reported previously that subclinical prolonged mild T helper (Th) 1-dependent autoimmune insulitis with impaired glucose tolerance in wealing DBA/1J mice, which is induced by the combined effects of reovirus type 2 (Reo-2) and synthetic 20-base oligodeoxynucleotides with CpG motifs (CpG ODN) (control mice). Co...

journal_title：Scandinavian journal of immunology

authors： Hayashi T,Hasegawa K,Sasaki Y,Onodera T

更新日期：2006-02-01 00:00:00

abstract：:In a well-established murine abortion model, stress is thought to trigger fetal rejection by inducing a proinflammatory immune response via substance P (SP), being tumour necrosis factor (TNF)-alpha-producing CD8+ T cells involved. Interestingly, the SP metabolite SP5-11 also binds to SP receptors and mediates SP-like...

journal_title：Scandinavian journal of immunology

authors： Fest S,Zenclussen AC,Joachim R,Hagen E,Demuth HU,Hoffmann T

更新日期：2006-01-01 00:00:00

abstract：:Contagious bovine pleuropneumonia, caused by Mycoplasma mycoides ssp. mycoides biotype small colony (MmmSC), is one of the most serious cattle diseases in Africa. Several observations suggested that MmmSC had evolved an efficient way to escape the bovine immune responses by triggering host-cell cytotoxicity. This stud...

journal_title：Scandinavian journal of immunology

authors： Dedieu L,Chapey E,Balcer-Rodrigues V

更新日期：2005-12-01 00:00:00

abstract：:In subjects not developing allergy, inhalation of nonpathogenic protein antigens causes no harm and is associated with tolerance induction. Repeated exposure to aerosolized ovalbumin (OVA) likewise does not evoke airway inflammation and induces inhalation tolerance in experimental animals. The present study explored t...

journal_title：Scandinavian journal of immunology

authors： Alenmyr L,Matheu V,Uller L,Greiff L,Malm-Erjefält M,Ljunggren HG,Persson CG,Korsgren M

更新日期：2005-11-01 00:00:00

abstract：:To study the role of Natural Killer (NK) cells in Leishmania infection, peritoneal macrophages from BALB/c mice were infected with Leishmania (Leishmania) amazonensis promastigotes and incubated with interleukin-2 (IL-2)-activated NK (A-NK) cells at different ratios of A-NK cells to infected macrophages (5:1, 1:1, 0.2...

journal_title：Scandinavian journal of immunology

authors： Aranha FC,Ribeiro U Jr,Basse P,Corbett CE,Laurenti MD

更新日期：2005-10-01 00:00:00

abstract：:The complement system is regarded as an important component of the innate defence system against invading bacteria. However, synergistic actions between the complement and the other components of innate immunity are incompletely known. Human group IIA phospholipase A(2) (hGIIA PLA(2)) is an effective antibacterial enz...

journal_title：Scandinavian journal of immunology

authors： Grönroos JO,Salonen JH,Viander M,Nevalainen TJ,Laine VJ

更新日期：2005-10-01 00:00:00

abstract：:T-cell sensitization to indirectly presented alloantigens (indirect pathway of allorecognition) plays a critical role in chronic rejection. The usual very efficient priming of such self-restricted, T helper type 1 (Th1)-deviated CD4+ T cells obviously conflicts with the fact that allogeneic MHC molecules are poorly im...

journal_title：Scandinavian journal of immunology

authors： Wallgren AC,Andersson B,Bäcker A,Karlsson-Parra A

更新日期：2005-09-01 00:00:00

abstract：:Natural killer (NK) cells represent the first line of defence against viral infections but, in the case of hepatitis B virus (HBV), may also be involved in liver injury. We here compared NK-cell activity of 11 patients with acute HBV infection, either HIV-positive or HIV-negative, with that of 11 healthy subjects. One...

journal_title：Scandinavian journal of immunology

authors： Morsica G,Tasca S,Biswas P,Galli A,Malnati M,Paties C,Marinelli M,Bagaglio S,Lazzarin A,Fortis C

更新日期：2005-09-01 00:00:00

abstract：:G-protein-coupled receptors play a major role in the activation of the innate immune system, such as polymorphonuclear neutrophils. Members of the formyl peptide receptor family recognize chemotactic peptides as well the amyloïd-beta peptide and fragments of the human immunodeficiency virus envelope and may thus be im...

journal_title：Scandinavian journal of immunology

authors： Boxio R,Bossenmeyer-Pourié C,Vanderesse R,Dournon C,Nüsse O

更新日期：2005-08-01 00:00:00

abstract：:The demonstration in the 1960s that T cells collaborated with B cells in enabling antibody responses to simple protein antigens opened up the challenge of how to investigate the interactions of two rare antigen-specific lymphocytes within a vast population. One idea was that T cells made soluble factors that could act...

journal_title：Scandinavian journal of immunology

authors： Waldmann H

更新日期：2005-07-01 00:00:00

abstract：:Proteins immobilized on insoluble carriers or immunoadsorbents are now widely used in many areas of biological research. They are especially efficient in studies of complex protein mixtures because immunoadsorbents are very useful for isolation of individual components for further investigation. Antibodies immobilized...

journal_title：Scandinavian journal of immunology

authors： Nezlin R

更新日期：2005-07-01 00:00:00

abstract：:Gangliosides are complex glycosphingolipids, which exert immune-modulating effects on various cell types. Ganglioside GD(3) and GM(3) are the predominant gangliosides of human breast milk but during the early phase of lactation, the content of GD(3) decreases while GM(3) increases. The biological value of gangliosides...

journal_title：Scandinavian journal of immunology

authors： Brønnum H,Seested T,Hellgren LI,Brix S,Frøkiaer H

更新日期：2005-06-01 00:00:00

abstract：:In this study, we discuss the use of glycopeptides containing tumour-associated carbohydrate antigens (TACA) as preventive vaccines for carcinomas. The results of our recent studies suggest that CD8(+) cytotoxic T cells are capable of recognizing small TACA in a conventional class I MHC-restricted fashion. TACA-specif...

journal_title：Scandinavian journal of immunology

authors： Franco A

更新日期：2005-05-01 00:00:00

abstract：:Colon cancer (CC) is one of the most common malignancies in the Western world. Although surgical resection is the first choice worldwide, at this point an effective approach for the treatment of patients with metastasis and cancer recurrence post-operation has not yet been found. The aim of this study was to investiga...

journal_title：Scandinavian journal of immunology

authors： Xu F,Ye YJ,Cui ZR,Wang S

更新日期：2005-04-01 00:00:00

abstract：:Extracts of the leaves and roots from the tree Artocarpus tonkinensis A Cheval (family Moraceae) are used in traditional Vietnamese medicine in order to treat backache as well as rheumatic joint diseases. We prepared an ethyl acetate (EtOAc) extract from this plant and tested its anti-inflammatory properties in an exp...

journal_title：Scandinavian journal of immunology

authors： Ngoc DD,Catrina AI,Lundberg K,Harris HE,Ha NT,Anh PT,Larsson P

更新日期：2005-03-01 00:00:00

abstract：:Proteins secreted by Mycobacterium tuberculosis are targets of host immune responses and as such are investigated for vaccine and immunodiagnostics development. Computer-driven searches of the M. tuberculosis H37Rv genome had previously identified 45 novel secreted proteins. Here, we report the characterization of the...

journal_title：Scandinavian journal of immunology

authors： Ben Amor Y,Shashkina E,Johnson S,Bifani PJ,Kurepina N,Kreiswirth B,Bhattacharya S,Spencer J,Rendon A,Catanzaro A,Gennaro ML

更新日期：2005-02-01 00:00:00

abstract：:We investigated dietary antigen-specific T-cell responses in mesenteric lymph nodes (MLN) and Peyer's patches (PP) in noncolitic control mice as well as in colitis-prone mice prior to onset of histological active colitis. T cells were restimulated in vitro with constituents isolated from the mouse diet. Interestingly,...

journal_title：Scandinavian journal of immunology

authors： Bjursten M,Hultgren Hörnquist E

更新日期：2005-01-01 00:00:00

abstract：:Modulation of cytotoxic responses by viral immunoevasins plays an important role in the establishment of latent and persistent viral infections. Together with MHC class-I-restricted CD8T-lymphocytes, non-MHC-restricted natural killer (NK) and lymphokine-activated killer (LAK) cells participate in this anti-viral contr...

journal_title：Scandinavian journal of immunology

authors： Cartier A,Masucci MG

更新日期：2004-12-01 00:00:00

abstract：:To further investigate the interaction between human mononuclear leucocytes [peripheral blood mononuclear cells (PBMC)] and enterocytes, the effect of a confluent layer of differentiated CACO-2 cells on cytokine kinetics during challenge with bacteria in a compartmentalized coculture model was investigated. Nonpathoge...

journal_title：Scandinavian journal of immunology

authors： Parlesak A,Haller D,Brinz S,Baeuerlein A,Bode C

更新日期：2004-11-01 00:00:00

abstract：:There still exist many unanswered questions whether physical exercise is beneficial or harmful to the immune system. The 'open-window' post-exercise hypothesis states that athletes are more susceptible to infections after exercise, but there is a need for further elucidation. The aim of the present study was to invest...

journal_title：Scandinavian journal of immunology

authors： Nielsen HG,Lyberg T

更新日期：2004-10-01 00:00:00